White Matter Hyperintensities in Mild Cognitive Impairment and Lower Risk of Cognitive Decline.

TitleWhite Matter Hyperintensities in Mild Cognitive Impairment and Lower Risk of Cognitive Decline.
Publication TypeJournal Article
Year of Publication2015
AuteursNolze-Charron, G, Mouiha, A, Duchesne, S, Bocti, C
Corporate AuthorsAlzheimer's Disease Neuroimaging Initiative1
JournalJ Alzheimers Dis
Volume46
Issue4
Pagination855-62
Date Published2015
ISSN1875-8908
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Cognition Disorders, Databases, Factual, Disease Progression, Executive Function, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Status Schedule, Neuropsychological Tests, Peptide Fragments, Psychiatric Status Rating Scales, Retrospective Studies, Statistics, Nonparametric, tau Proteins, White Matter
Abstract

BACKGROUND: White matter hyperintensities (WMH) may have a different impact on cognitive decline depending on strategic localization.OBJECTIVE: The goal of this study is to assess the impact of global and cholinergic WMH on cognitive decline of mild cognitive impairment (MCI) patients in the ADNI-1 dataset.METHODS: This is a retrospective analysis of data from a natural history study. MRI scans (T2 and PD sequences) were assessed with two visual scales: 1) The Cholinergic Pathways HyperIntensities Scale (CHIPS) score, designed to assess WMH in the cholinergic tracts, and 2) the Age-Related White Matter Changes Scale (ARWMC), a scale to assess the global WMH burden. All subjects underwent standardized neuropsychological testing.RESULTS: Subjects included 310 individuals with MCI. Analysis showed no association between WMH at baseline and conversion from MCI to Alzheimer's disease (AD), either for the global WMH burden or WMH within the cholinergic pathways. However, ARWMC scores had a significant confounding effect (p = 0.03) on conversion to dementia (hazard ratio of 0.37) among MCI subjects with low executive functions.CONCLUSION: We found no association between the burden of WMH at baseline in MCI and conversion to AD over 3 years. However, a higher global WMH burden appears to reduce the risk of conversion to AD in subjects with low executive functions. These results suggest that higher WMH burden in MCI individuals may be associated with a more gradual cognitive decline or stabilization, compared to a low WMH burden.

DOI10.3233/JAD-140618
Alternate JournalJ. Alzheimers Dis.
PubMed ID26402625
Grant ListU01 AG024904 / AG / NIA NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada