In vivo live imaging of postnatal neural stem cells.

TitleIn vivo live imaging of postnatal neural stem cells.
Publication TypeJournal Article
Year of Publication2021
AuteursMarymonchyk, A, Malvaut, S, Saghatelyan, A
JournalDevelopment
Volume148
Issue18
Date Published2021 09 15
ISSN1477-9129
KeywordsAnimals, Brain, Cell- and Tissue-Based Therapy, Humans, Neural Stem Cells, Postnatal Care, Signal Transduction
Abstract

Neural stem cells (NSCs) are maintained in specific regions of the postnatal brain and contribute to its structural and functional plasticity. However, the long-term renewal potential of NSCs and their mode of division remain elusive. The use of advanced in vivo live imaging approaches may expand our knowledge of NSC physiology and provide new information for cell replacement therapies. In this Review, we discuss the in vivo imaging methods used to study NSC dynamics and recent live-imaging results with respect to specific intracellular pathways that allow NSCs to integrate and decode different micro-environmental signals. Lastly, we discuss future directions that may provide answers to unresolved questions regarding NSC physiology.

DOI10.1242/dev.199778
Alternate JournalDevelopment
PubMed ID34383894
Grant List / / CIHR / Canada