Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.

TitleUncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.
Publication TypeJournal Article
Year of Publication2018
AuteursYoung, AL, Marinescu, RV, Oxtoby, NP, Bocchetta, M, Yong, K, Firth, NC, Cash, DM, Thomas, DL, Dick, KM, Cardoso, J, van Swieten, J, Borroni, B, Galimberti, D, Masellis, M, Tartaglia, MCarmela, Rowe, JB, Graff, C, Tagliavini, F, Frisoni, GB, Laforce, Jr, R, Finger, E, de Mendonça, A, Sorbi, S, Warren, JD, Crutch, S, Fox, NC, Ourselin, S, Schott, JM, Rohrer, JD, Alexander, DC
Corporate AuthorsGenetic FTD Initiative (GENFI), Alzheimer’s Disease Neuroimaging Initiative (ADNI)
JournalNat Commun
Volume9
Issue1
Pagination4273
Date Published2018 10 15
ISSN2041-1723
Abstract

The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning technique-Subtype and Stage Inference (SuStaIn)-able to uncover data-driven disease phenotypes with distinct temporal progression patterns, from widely available cross-sectional patient studies. Results from imaging studies in two neurodegenerative diseases reveal subgroups and their distinct trajectories of regional neurodegeneration. In genetic frontotemporal dementia, SuStaIn identifies genotypes from imaging alone, validating its ability to identify subtypes; further the technique reveals within-genotype heterogeneity. In Alzheimer's disease, SuStaIn uncovers three subtypes, uniquely characterising their temporal complexity. SuStaIn provides fine-grained patient stratification, which substantially enhances the ability to predict conversion between diagnostic categories over standard models that ignore subtype (p = 7.18 × 10) or temporal stage (p = 3.96 × 10). SuStaIn offers new promise for enabling disease subtype discovery and precision medicine.

DOI10.1038/s41467-018-05892-0
Alternate JournalNat Commun
PubMed ID30323170
PubMed Central IDPMC6189176
Grant List / / Wellcome Trust / United Kingdom
U01 AG024904 / AG / NIA NIH HHS / United States