Stress and Loss of Ovarian Function: Novel Insights into the Origins of Sex-Based Differences in the Manifestations of Respiratory Control Disorders During Sleep.

TitleStress and Loss of Ovarian Function: Novel Insights into the Origins of Sex-Based Differences in the Manifestations of Respiratory Control Disorders During Sleep.
Publication TypeJournal Article
Year of Publication2021
AuteursKinkead, R, Gagnon, M, Joseph, V, Sériès, F, Ambrozio-Marques, D
JournalClin Chest Med
Volume42
Issue3
Pagination391-405
Date Published2021 09
ISSN1557-8216
KeywordsComorbidity, Female, Humans, Male, Respiration Disorders, Sex Characteristics, Sleep, Sleep Apnea Syndromes
Abstract

The respiratory system of women and men develops and functions in distinct neuroendocrine milieus. Despite differences in anatomy and neural control, homeostasis of arterial blood gases is ensured in healthy individuals regardless of sex. This convergence in function differs from the sex-based differences observed in many respiratory diseases. Sleep-disordered breathing (SDB) results mainly from episodes of upper airway closure. This complex and multifactorial respiratory disorder shows significant sexual dimorphism in its clinical manifestations and comorbidities. Guided by recent progress from basic research, this review discusses the hypothesis that stress is necessary to reveal the sexual dimorphism of SDB.

DOI10.1016/j.ccm.2021.04.002
Alternate JournalClin Chest Med
PubMed ID34353446