Role of the Endocannabinoidome in Human and Mouse Atherosclerosis.

TitleRole of the Endocannabinoidome in Human and Mouse Atherosclerosis.
Publication TypeJournal Article
Year of Publication2019
AuteursPiscitelli, F, Silvestri, C
JournalCurr Pharm Des
Volume25
Issue29
Pagination3147-3164
Date Published2019
ISSN1873-4286
Abstract

The Endocannabinoid (eCB) system and its role in many physiological and pathological conditions is well described and accepted, and includes cardiovascular disorders. However, the eCB system has been expanded to an "-ome"; the endocannabinoidome (eCBome) that includes endocannabinoid-related mediators, their protein targets and metabolic enzymes, many of which significantly impact upon cardiometabolic health. These recent discoveries are here summarized with a special focus on their potential involvement in atherosclerosis. We described the role of classical components of the eCB system (eCBs, CB1 and CB2 receptors) and eCB-related lipids, their regulatory enzymes and molecular targets in atherosclerosis. Furthermore, since increasing evidence points to significant cross-talk between the eCBome and the gut microbiome and the gut microbiome and atherosclerosis, we explore the possibility that a gut microbiome - eCBome axis has potential implications in atherosclerosis.

DOI10.2174/1381612825666190826162735
Alternate JournalCurr. Pharm. Des.
PubMed ID31448709