Reward processing by the lateral habenula in normal and depressive behaviors.

TitleReward processing by the lateral habenula in normal and depressive behaviors.
Publication TypeJournal Article
Year of Publication2014
AuteursProulx, CD, Hikosaka, O, Malinow, R
JournalNat Neurosci
Volume17
Issue9
Pagination1146-52
Date Published2014 Sep
ISSN1546-1726
KeywordsAnimals, Depressive Disorder, Major, Dopamine, Habenula, Humans, Reward, Serotonin
Abstract

The brain reward circuit has a central role in reinforcing behaviors that are rewarding and preventing behaviors that lead to punishment. Recent work has shown that the lateral habenula is an important part of the reward circuit by providing 'negative value' signals to the dopaminergic and serotonergic systems. Studies have also suggested that dysfunction of the lateral habenula is associated with psychiatric disorders, including major depression. Here, we discuss insights gained from neuronal recordings in monkeys regarding how the lateral habenula processes reward-related information. We then highlight recent optogenetic experiments in rodents addressing normal and abnormal functions of the habenula. Finally, we discuss how deregulation of the lateral habenula may be involved in depressive behaviors.

DOI10.1038/nn.3779
Alternate JournalNat. Neurosci.
PubMed ID25157511
PubMed Central IDPMC4305435
Grant ListR01 MH091119 / MH / NIMH NIH HHS / United States