Regulation of brain insulin signaling: A new function for tau.

TitleRegulation of brain insulin signaling: A new function for tau.
Publication TypeJournal Article
Year of Publication2017
AuteursGratuze, M, Planel, E
JournalJ Exp Med
Volume214
Issue8
Pagination2171-2173
Date Published2017 Aug 07
ISSN1540-9538
KeywordsAlzheimer Disease, Brain, Humans, Insulin, Phosphorylation, Signal Transduction, tau Proteins
Abstract

In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function.

DOI10.1084/jem.20170979
Alternate JournalJ. Exp. Med.
PubMed ID28652305
PubMed Central IDPMC5551584