| Title | Regulation of brain insulin signaling: A new function for tau. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Auteurs | Gratuze, M, Planel, E |
| Journal | J Exp Med |
| Volume | 214 |
| Issue | 8 |
| Pagination | 2171-2173 |
| Date Published | 2017 Aug 07 |
| ISSN | 1540-9538 |
| Keywords | Alzheimer Disease, Brain, Humans, Insulin, Phosphorylation, Signal Transduction, tau Proteins |
| Abstract | In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function. |
| DOI | 10.1084/jem.20170979 |
| Alternate Journal | J. Exp. Med. |
| PubMed ID | 28652305 |
| PubMed Central ID | PMC5551584 |