Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation.

TitleOperationalizing protocol differences for EADC-ADNI manual hippocampal segmentation.
Publication TypeJournal Article
Year of Publication2015
AuteursBoccardi, M, Bocchetta, M, Ganzola, R, Robitaille, N, Redolfi, A, Duchesne, S, Jack, CR, Frisoni, GB
Corporate AuthorsEADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative
JournalAlzheimers Dement
Date Published2015 Feb
KeywordsAged, Alzheimer Disease, Atrophy, Cognitive Dysfunction, Delphi Technique, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Neuroimaging, Organ Size, Reproducibility of Results

BACKGROUND: Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks.METHODS: One hundred percent of anatomic landmark variability across 12 different protocols for manual segmentation was reduced into four segmentation units (the minimum hippocampus, the alveus/fimbria, the tail, and the subiculum), which were segmented on magnetic resonance images by expert raters to estimate reliability and AD-related atrophy.RESULTS: Intra- and interrater reliability were more than 0.96 and 0.92, respectively, except for the alveus/fimbria, which were 0.86 and 0.77, respectively. Of all AD-related atrophy, the minimum hippocampus contributed to 67%; tail, 24%; alveus/fimbria, 4%; and the subiculum, 5%.CONCLUSIONS: Anatomic landmark variability in available protocols can be reduced to four discrete and measurable segmentation units. Their quantitative assessment will help a Delphi panel to define a set of landmarks for a harmonized protocol.

Alternate JournalAlzheimers Dement
PubMed ID23706515
Grant ListK01 AG030514 / AG / NIA NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States