Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation.

TitleOperationalizing protocol differences for EADC-ADNI manual hippocampal segmentation.
Publication TypeJournal Article
Year of Publication2015
AuteursBoccardi, M, Bocchetta, M, Ganzola, R, Robitaille, N, Redolfi, A, Duchesne, S, Jack, CR, Frisoni, GB
Corporate AuthorsEADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative
JournalAlzheimers Dement
Volume11
Issue2
Pagination184-94
Date Published2015 Feb
ISSN1552-5279
KeywordsAged, Alzheimer Disease, Atrophy, Cognitive Dysfunction, Delphi Technique, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Neuroimaging, Organ Size, Reproducibility of Results
Abstract

BACKGROUND: Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks.METHODS: One hundred percent of anatomic landmark variability across 12 different protocols for manual segmentation was reduced into four segmentation units (the minimum hippocampus, the alveus/fimbria, the tail, and the subiculum), which were segmented on magnetic resonance images by expert raters to estimate reliability and AD-related atrophy.RESULTS: Intra- and interrater reliability were more than 0.96 and 0.92, respectively, except for the alveus/fimbria, which were 0.86 and 0.77, respectively. Of all AD-related atrophy, the minimum hippocampus contributed to 67%; tail, 24%; alveus/fimbria, 4%; and the subiculum, 5%.CONCLUSIONS: Anatomic landmark variability in available protocols can be reduced to four discrete and measurable segmentation units. Their quantitative assessment will help a Delphi panel to define a set of landmarks for a harmonized protocol.

DOI10.1016/j.jalz.2013.03.001
Alternate JournalAlzheimers Dement
PubMed ID23706515
Grant ListK01 AG030514 / AG / NIA NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States