MicroRNAs underlying memory deficits in neurodegenerative disorders.

TitleMicroRNAs underlying memory deficits in neurodegenerative disorders.
Publication TypeJournal Article
Year of Publication2017
AuteursHernandez-Rapp, J, Rainone, S, Hébert, SS
JournalProg Neuropsychopharmacol Biol Psychiatry
Volume73
Pagination79-86
Date Published2017 Feb 06
ISSN1878-4216
KeywordsAnimals, Humans, Memory Disorders, MicroRNAs, Neurodegenerative Diseases
Abstract

Neurodegenerative disorders are defined by neuronal loss and often associated with dementia. Understanding the multifactorial nature of cognitive decline is of particular interest. Cell loss is certainly a possibility but also an early imbalance in the complex gene networks involved in learning and memory. The small (~22nt) non-coding microRNAs play a major role in gene expression regulation and have been linked to neuronal survival and cognition. Interestingly, changes in microRNA signatures are associated with neurodegenerative disorders. In this review, we explore the role of three microRNAs, namely miR-132, miR-124 and miR-34, which are dysregulated in major neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Interestingly, these microRNAs have been associated with both memory impairment and neuronal survival, providing a potential common molecular mechanism contributing to dementia.

DOI10.1016/j.pnpbp.2016.04.011
Alternate JournalProg. Neuropsychopharmacol. Biol. Psychiatry
PubMed ID27117821