Metaflumizone inhibits the honeybee NaV 1 channel by targeting recovery from slow inactivation.

TitleMetaflumizone inhibits the honeybee NaV 1 channel by targeting recovery from slow inactivation.
Publication TypeJournal Article
Year of Publication2017
AuteursGosselin-Badaroudine, P, Charnet, P, Collet, C, Chahine, M
JournalFEBS Lett
Volume591
Issue23
Pagination3842-3849
Date Published2017 Dec
ISSN1873-3468
Abstract

Metaflumizone is the latest addition to the armamentarium of the Na+ channel inhibitor insecticide family. We used the Xenopus oocyte expression system and a Markovian model to assess the effect of metaflumizone on Apis mellifera Na+ channels (AmNaV 1). Our results reveal that metaflumizone inhibits AmNaV 1 channels by targeting the kinetics of recovery from slow inactivation. Multistate modeling of fast and slow inactivation of the AmNaV 1 channel made it possible to study the effects of metaflumizone on a set of rate constants underlying the transition between the open and inactivated conformations and provided insights into their specificity. We conclude that the methods we used could be extended to assessing the toxicity of other Na+ channel inhibitor insecticides.

DOI10.1002/1873-3468.12897
Alternate JournalFEBS Lett.
PubMed ID29105054