Metabolic determinants of Alzheimer's disease: A focus on thermoregulation.

TitleMetabolic determinants of Alzheimer's disease: A focus on thermoregulation.
Publication TypeJournal Article
Year of Publication2021
AuteursTournissac, M, Leclerc, M, Valentin-Escalera, J, Vandal, M, Bosoi, CR, Planel, E, Calon, F
JournalAgeing Res Rev
Volume72
Pagination101462
Date Published2021 12
ISSN1872-9649
KeywordsAdipose Tissue, Brown, Aged, Alzheimer Disease, Body Temperature Regulation, Energy Metabolism, Humans, Neurodegenerative Diseases, Thermogenesis
Abstract

Alzheimer's disease (AD) is a complex age-related neurodegenerative disease, associated with central and peripheral metabolic anomalies, such as impaired glucose utilization and insulin resistance. These observations led to a considerable interest not only in lifestyle-related interventions, but also in repurposing insulin and other anti-diabetic drugs to prevent or treat dementia. Body temperature is the oldest known metabolic readout and mechanisms underlying its maintenance fail in the elderly, when the incidence of AD rises. This raises the possibility that an age-associated thermoregulatory deficit contributes to energy failure underlying AD pathogenesis. Brown adipose tissue (BAT) plays a central role in thermogenesis and maintenance of body temperature. In recent years, the modulation of BAT activity has been increasingly demonstrated to regulate energy expenditure, insulin sensitivity and glucose utilization, which could also provide benefits for AD. Here, we review the evidence linking thermoregulation, BAT and insulin-related metabolic defects with AD, and we propose mechanisms through which correcting thermoregulatory impairments could slow the progression and delay the onset of AD.

DOI10.1016/j.arr.2021.101462
Alternate JournalAgeing Res Rev
PubMed ID34534683
Grant ListPJT 156054 / / CIHR / Canada
PJT 168927 / / CIHR / Canada