Memory formation and retention are affected in adult miR-132/212 knockout mice.

TitleMemory formation and retention are affected in adult miR-132/212 knockout mice.
Publication TypeJournal Article
Year of Publication2015
AuteursHernandez-Rapp, J, Smith, PY, Filali, M, Goupil, C, Planel, E, Magill, ST, Goodman, RH, Hébert, SS
JournalBehav Brain Res
Volume287
Pagination15-26
Date Published2015
ISSN1872-7549
KeywordsAnimals, Anxiety, Brain-Derived Neurotrophic Factor, Cyclic AMP Response Element-Binding Protein, Male, Maze Learning, Methyl-CpG-Binding Protein 2, Mice, Mice, Inbred C57BL, Mice, Knockout, MicroRNAs, Motor Activity, Phosphorylation, Recognition (Psychology), Retention (Psychology), Spatial Memory
Abstract

The miR-132/212 family is thought to play an important role in neural function and plasticity, while its misregulation has been observed in various neurodegenerative disorders. In this study, we analyzed 6-month-old miR-132/212 knockout mice in a battery of cognitive and non-cognitive behavioral tests. No significant changes were observed in reflexes and basic sensorimotor functions as determined by the SHIRPA primary screen. Accordingly, miR-132/212 knockout mice did not differ from wild-type controls in general locomotor activity in an open-field test. Furthermore, no significant changes of anxiety were measured in an elevated plus maze task. However, the mutant mice showed retention phase defects in a novel object recognition test and in the T-water maze. Moreover, the learning and probe phases in the Barnes maze were clearly altered in knockout mice when compared to controls. Finally, changes in BDNF, CREB, and MeCP2 were identified in the miR-132/212-deficient mice, providing a potential mechanism for promoting memory loss. Taken together, these results further strengthen the role of miR-132/212 in memory formation and retention, and shed light on the potential consequences of its deregulation in neurodegenerative diseases.

DOI10.1016/j.bbr.2015.03.032
Alternate JournalBehav. Brain Res.
PubMed ID25813747
Grant ListR01 MH094416 / MH / NIMH NIH HHS / United States
MH094416 / MH / NIMH NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada