Measuring how genetic and epigenetic variants can filter emotion perception.

TitleMeasuring how genetic and epigenetic variants can filter emotion perception.
Publication TypeJournal Article
Year of Publication2015
AuteursTaschereau-Dumouchel, V, Hétu, S, Chagnon, YC, Jackson, PL
JournalPsychiatr Genet
Volume25
Issue5
Pagination216-22
Date Published2015 Oct
ISSN1473-5873
KeywordsBrain, Cognition, Emotions, Epigenesis, Genetic, Epistasis, Genetic, Gene-Environment Interaction, Genetic Variation, Humans
Abstract

Emotion perception has been extensively studied in cognitive neurosciences and stands as a promising intermediate phenotype of social cognitive processes and psychopathologies. Exciting imaging genetic studies have recently identified genetic and epigenetic variants affecting brain responses during emotion perception tasks, but characterizing how these variants interact and relate to higher-order cognitive processes remains a challenge. Here, we integrate works in parallel fields and propose a new psychophysical conceptualization to address this issue. This approach proposes to consider genetic variants as 'filters' of perceptual information that can interact to shape different perceptual profiles. Importantly, these perceptual profiles can be precisely described and compared between multivariate genetic groups using a new psychophysical method. Crucially, this approach represents a potentially powerful novel tool to address gene-by-gene and gene-by-environment interactions, and provides a new cognitive perspective to link social perceptive and social cognitive processes in the context of psychiatric disorders.

DOI10.1097/YPG.0000000000000102
Alternate JournalPsychiatr. Genet.
PubMed ID26301725
Grant List / / Canadian Institutes of Health Research / Canada