Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin.

TitleInput to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin.
Publication TypeJournal Article
Year of Publication2012
AuteursShabel, SJ, Proulx, CD, Trias, A, Murphy, RT, Malinow, R
JournalNeuron
Volume74
Issue3
Pagination475-81
Date Published2012 May 10
ISSN1097-4199
KeywordsAnimals, Animals, Newborn, Avoidance Learning, Basal Ganglia, Biophysics, Channelrhodopsins, Cholera Toxin, Conditioning, Operant, Dopamine, Electric Stimulation, Excitatory Amino Acid Antagonists, Excitatory Amino Acids, Glutamate Decarboxylase, Habenula, Humans, In Vitro Techniques, Light, Luminescent Proteins, Membrane Potentials, Nerve Tissue Proteins, Neural Pathways, Neurons, Optics and Photonics, Patch-Clamp Techniques, Quinoxalines, Rats, Rats, Sprague-Dawley, Serotonin, Time Factors, Transduction, Genetic, Vesicular Glutamate Transport Protein 2
Abstract

The lateral habenula (LHb) has recently been identified as a key regulator of the reward system by driving inhibition onto dopaminergic neurons. However, the nature and potential modulation of the major input to the LHb originating from the basal ganglia are poorly understood. Although the output of the basal ganglia is thought to be primarily inhibitory, here we show that transmission from the basal ganglia to the LHb is excitatory, glutamatergic, and suppressed by serotonin. Behaviorally, activation of this pathway is aversive, consistent with its role as an "antireward" signal. Our demonstration of an excitatory projection from the basal ganglia to the LHb explains how LHb-projecting basal ganglia neurons can have similar encoding properties as LHb neurons themselves. Our results also provide a link between antireward excitatory synapses and serotonin, a neuromodulator implicated in depression.

DOI10.1016/j.neuron.2012.02.037
Alternate JournalNeuron
PubMed ID22578499
PubMed Central IDPMC3471532
Grant ListR01 MH049159-21 / MH / NIMH NIH HHS / United States
R01 AG032132 / AG / NIA NIH HHS / United States
R01 AG032132-14 / AG / NIA NIH HHS / United States
R01 MH091119-01A1 / MH / NIMH NIH HHS / United States
R01 MH091119 / MH / NIMH NIH HHS / United States
R01 MH049159 / MH / NIMH NIH HHS / United States