The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.

TitleThe inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.
Publication TypeJournal Article
Year of Publication2019
AuteursPremi, E, Calhoun, VD, Diano, M, Gazzina, S, Cosseddu, M, Alberici, A, Archetti, S, Paternicò, D, Gasparotti, R, van Swieten, J, Galimberti, D, Sanchez-Valle, R, Laforce, Jr, R, Moreno, F, Synofzik, M, Graff, C, Masellis, M, Tartaglia, MCarmela, Rowe, J, Vandenberghe, R, Finger, E, Tagliavini, F, de Mendonça, A, Santana, I, Butler, C, Ducharme, S, Gerhard, A, Danek, A, Levin, J, Otto, M, Frisoni, G, Cappa, S, Sorbi, S, Padovani, A, Rohrer, JD, Borroni, B
Corporate AuthorsGenetic FTD Initiative, GENFI
JournalNeuroimage
Volume189
Pagination645-654
Date Published2019 Apr 01
ISSN1095-9572
Abstract

Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. We considered 249 subjects with FTD-related pathogenetic mutations and 223 mutation non-carriers (HC). Dynamic connectivity was evaluated using independent component analysis and sliding-time window correlation to rs-fMRI data, and meta-state measures of global brain flexibility were extracted. Results show that presymptomatic FTD exhibits diminished dynamic fluidity, visiting less meta-states, shifting less often across them, and travelling through a narrowed meta-state distance, as compared to HC. Dynamic connectivity changes characterize preclinical FTD, arguing for the desynchronization of the inner fluctuations of the brain. These changes antedate clinical symptoms, and might represent an early signature of FTD to be used as a biomarker in clinical trials.

DOI10.1016/j.neuroimage.2019.01.080
Alternate JournalNeuroimage
PubMed ID30716457
Grant ListMC_U105597119 / / Medical Research Council / United Kingdom
MR/J009482/1 / / Medical Research Council / United Kingdom
MR/M023664/1 / / Medical Research Council / United Kingdom
MR/K010395/1 / / Medical Research Council / United Kingdom
MR/M008525/1 / / Medical Research Council / United Kingdom
MR/M009106/1 / / Medical Research Council / United Kingdom