Harmonized benchmark labels of the hippocampus on magnetic resonance: the EADC-ADNI project.

TitleHarmonized benchmark labels of the hippocampus on magnetic resonance: the EADC-ADNI project.
Publication TypeJournal Article
Year of Publication2015
AuteursBocchetta, M, Boccardi, M, Ganzola, R, Apostolova, LG, Preboske, G, Wolf, D, Ferrari, C, Pasqualetti, P, Robitaille, N, Duchesne, S, Jack, CR, Frisoni, GB
Corporate AuthorsEADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative
JournalAlzheimers Dement
Date Published2015 Feb
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cognitive Dysfunction, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Inservice Training, Magnetic Resonance Imaging, Male, Neuroimaging, Organ Size, Reproducibility of Results

BACKGROUND: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation.METHODS: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 T and 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes.RESULTS: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- and interrater ICCs were >0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76).CONCLUSION: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

Alternate JournalAlzheimers Dement
PubMed ID25223727
Grant ListK01 AG030514 / AG / NIA NIH HHS / United States
P30AG010129 / AG / NIA NIH HHS / United States
U01AG024904 / AG / NIA NIH HHS / United States