The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus.

TitleThe Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus.
Publication TypeJournal Article
Year of Publication2019
AuteursVeilleux, A, Di Marzo, V, Silvestri, C
JournalCurr Diab Rep
Volume19
Issue11
Pagination117
Date Published2019 Nov 04
ISSN1539-0829
Abstract

PURPOSE OF REVIEW: The endocannabinoid (eCB) system, i.e. the receptors that respond to the psychoactive component of cannabis, their endogenous ligands and the ligand metabolic enzymes, is part of a larger family of lipid signals termed the endocannabinoidome (eCBome). We summarize recent discoveries of the roles that the eCBome plays within peripheral tissues in diabetes, and how it is being targeted, in an effort to develop novel therapeutics for the treatment of this increasingly prevalent disease.RECENT FINDINGS: As with the eCB system, many eCBome members regulate several physiological processes, including energy intake and storage, glucose and lipid metabolism and pancreatic health, which contribute to the development of type 2 diabetes (T2D). Preclinical studies increasingly support the notion that targeting the eCBome may beneficially affect T2D. The eCBome is implicated in T2D at several levels and in a variety of tissues, making this complex lipid signaling system a potential source of many potential therapeutics for the treatments for T2D.

DOI10.1007/s11892-019-1248-9
Alternate JournalCurr. Diab. Rep.
PubMed ID31686231