Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice.

TitleErythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice.
Publication TypeJournal Article
Year of Publication2021
AuteursJacobs, RA, Aboouf, MA, Koester-Hegmann, C, Muttathukunnel, P, Laouafa, S, Arias-Reyes, C, Thiersch, M, Soliz, J, Gassmann, M, Gasser, EMSchneide
JournalCommun Biol
Date Published2021 08 05
KeywordsAnimals, Cognition, Erythropoietin, Hippocampus, Mice, Mice, Transgenic, Mitochondria, Neurons, Random Allocation

Erythropoietin (EPO) improves neuronal mitochondrial function and cognition in adults after brain injury and in those afflicted by psychiatric disorders. However, the influence of EPO on mitochondria and cognition during development remains unexplored. We previously observed that EPO stimulates hippocampal-specific neuronal maturation and synaptogenesis early in postnatal development in mice. Here we show that EPO promotes mitochondrial respiration in developing postnatal hippocampus by increasing mitochondrial content and enhancing cellular respiratory potential. Ultrastructurally, mitochondria profiles and total vesicle content were greater in presynaptic axon terminals, suggesting that EPO enhances oxidative metabolism and synaptic transmission capabilities. Behavioural tests of hippocampus-dependent memory at early adulthood, showed that EPO improves spatial and short-term memory. Collectively, we identify a role for EPO in the murine postnatal hippocampus by promoting mitochondrial function throughout early postnatal development, which corresponds to enhanced cognition by early adulthood.

Alternate JournalCommun Biol
PubMed ID34354241
PubMed Central IDPMC8342552