Engineering a memory with LTD and LTP.

TitleEngineering a memory with LTD and LTP.
Publication TypeJournal Article
Year of Publication2014
AuteursNabavi, S, Fox, R, Proulx, CD, Lin, JY, Tsien, RY, Malinow, R
JournalNature
Volume511
Issue7509
Pagination348-52
Date Published2014 Jul 17
ISSN1476-4687
KeywordsAmygdala, Animals, Conditioning (Psychology), Electric Stimulation, Electrophysiology, Fear, Long-Term Potentiation, Long-Term Synaptic Depression, Male, Memory, Optogenetics, Rats, Rats, Sprague-Dawley, Synapses, Synaptic Transmission
Abstract

It has been proposed that memories are encoded by modification of synaptic strengths through cellular mechanisms such as long-term potentiation (LTP) and long-term depression (LTD). However, the causal link between these synaptic processes and memory has been difficult to demonstrate. Here we show that fear conditioning, a type of associative memory, can be inactivated and reactivated by LTD and LTP, respectively. We began by conditioning an animal to associate a foot shock with optogenetic stimulation of auditory inputs targeting the amygdala, a brain region known to be essential for fear conditioning. Subsequent optogenetic delivery of LTD conditioning to the auditory input inactivates memory of the shock. Then subsequent optogenetic delivery of LTP conditioning to the auditory input reactivates memory of the shock. Thus, we have engineered inactivation and reactivation of a memory using LTD and LTP, supporting a causal link between these synaptic processes and memory.

DOI10.1038/nature13294
Alternate JournalNature
PubMed ID24896183
PubMed Central IDPMC4210354
Grant ListR01 AG032132 / AG / NIA NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
NS27177 / NS / NINDS NIH HHS / United States
R01 NS027177 / NS / NINDS NIH HHS / United States
MH049159 / MH / NIMH NIH HHS / United States
R37 NS027177 / NS / NINDS NIH HHS / United States
R37 MH049159 / MH / NIMH NIH HHS / United States
R01 MH091119 / MH / NIMH NIH HHS / United States
R01 MH049159 / MH / NIMH NIH HHS / United States