Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.

TitleDelphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.
Publication TypeJournal Article
Year of Publication2015
AuteursBoccardi, M, Bocchetta, M, Apostolova, LG, Barnes, J, Bartzokis, G, Corbetta, G, DeCarli, C, deToledo-Morrell, L, Firbank, M, Ganzola, R, Gerritsen, L, Henneman, W, Killiany, RJ, Malykhin, N, Pasqualetti, P, Pruessner, JC, Redolfi, A, Robitaille, N, Soininen, H, Tolomeo, D, Wang, L, Watson, C, Wolf, H, Duvernoy, H, Duchesne, S, Jack, CR, Frisoni, GB
Corporate AuthorsEADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation
JournalAlzheimers Dement
Date Published2015 Feb
KeywordsAlzheimer Disease, Atrophy, Consensus, Delphi Technique, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internationality, Magnetic Resonance Imaging, Neuroimaging

BACKGROUND: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.METHODS: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.RESULTS: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DISCUSSION: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

Alternate JournalAlzheimers Dement
PubMed ID25130658
PubMed Central IDPMC4419736
Grant ListP30 AG010129 / AG / NIA NIH HHS / United States
R01 AG042292 / AG / NIA NIH HHS / United States