Cytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury.

TitleCytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury.
Publication TypeJournal Article
Year of Publication2014
AuteursBastien, D, Lacroix, S
JournalExp Neurol
Volume258
Pagination62-77
Date Published2014 Aug
ISSN1090-2430
KeywordsAnimals, Cytokines, Humans, Leukocytes, Neuroglia, Peripheral Nerve Injuries, Signal Transduction, Spinal Cord Injuries
Abstract

Injury to the nervous system causes the almost immediate release of cytokines by glial cells and neurons. These cytokines orchestrate a complex array of responses leading to microgliosis, immune cell recruitment, astrogliosis, scarring, and the clearance of cellular debris, all steps that affect neuronal survival and repair. This review will focus on cytokines released after spinal cord and peripheral nerve injury and the primary signalling pathways triggered by these inflammatory mediators. Notably, the following cytokine families will be covered: IL-1, TNF, IL-6-like, TGF-β, and IL-10. Whether interfering with cytokine signalling could lead to novel therapies will also be discussed. Finally, the review will address whether manipulating the above-mentioned cytokine families and signalling pathways could exert distinct effects in the injured spinal cord versus peripheral nerve.

DOI10.1016/j.expneurol.2014.04.006
Alternate JournalExp. Neurol.
PubMed ID25017888
Grant ListMOP-84558 / / Canadian Institutes of Health Research / Canada