The central chemosensitivity is not altered by cerebral erythropoietin.

TitleThe central chemosensitivity is not altered by cerebral erythropoietin.
Publication TypeJournal Article
Year of Publication2015
AuteursBallot, O, Laouafa, S, Elliot-Portal, E, Tam, R, Voituron, N, Joseph, V, Soliz, J
JournalNeurosci Lett
Volume609
Pagination63-8
Date Published2015 Nov 16
ISSN1872-7972
KeywordsAge Factors, Animals, Animals, Newborn, Brain, Carbon Dioxide, Cisterna Magna, Erythropoietin, Female, Injections, Intraventricular, Male, Mice, Inbred C57BL, Oxygen, Receptors, Erythropoietin, Respiration
Abstract

The stimulation of central chemoreceptors by CO2 is considered essential for breathing. The supporting evidence include the fact that central apnea in neonates correlates with immaturity of the CO2-sensing mechanism, and that congenital central hypoventilation syndrome (CCHS) is characterized by the absence of a ventilatory response to elevated PCO2. We reported previously that cerebral erythropoietin (Epo) is a potent respiratory stimulant upon normoxia and hypoxia. The injection of soluble Epo receptor (sEpoR; the natural EpoR competitor to bind Epo) via the cisterna magna (ICI: intra-cisternal injection) decreases basal ventilation in adult and newborn mice. Moreover, sEpoR induces respiratory depression in adult and newborn mice exposed to hypoxia. In this study we tested the hypothesis that endogenous brain Epo also modulates the respiratory stimulation induced by the activation of central CO2 chemoreceptors. Adult and newborn male and female mice received an injection of sEpoR or vehicle via the cisterna magna. Twenty-four hours later basal minute ventilation and the ventilatory response to hypercapnia (5% CO2) were evaluated by plethysmography. Our results did not show a difference in the hypercapnic response between sEpoR and vehicle-injected male or female mice at postnatal or adult ages. We concluded that endogenous brain Epo does not contribute to modulating the PCO2-mediated central activation of breathing.

DOI10.1016/j.neulet.2015.10.026
Alternate JournalNeurosci. Lett.
PubMed ID26472708
Grant ListMOP 130258 / / Canadian Institutes of Health Research / Canada