Cancer treatments and their side effects are associated with aggravation of insomnia: Results of a longitudinal study.

TitleCancer treatments and their side effects are associated with aggravation of insomnia: Results of a longitudinal study.
Publication TypeJournal Article
Year of Publication2015
AuteursSavard, J, Ivers, H, Savard, M-H, Morin, CM
JournalCancer
Volume121
Issue10
Pagination1703-11
Date Published2015 May 15
ISSN1097-0142
KeywordsAdult, Aged, Aged, 80 and over, Antineoplastic Agents, Antineoplastic Agents, Hormonal, Breast Neoplasms, Canada, Chemotherapy, Adjuvant, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Prostatic Neoplasms, Quality of Life, Radiotherapy, Adjuvant, Severity of Illness Index, Sleep Initiation and Maintenance Disorders, Surveys and Questionnaires
Abstract

BACKGROUND: Insomnia affects between 30% to 60% of patients with cancer but to the authors' knowledge little is known regarding factors associated with its development. It has been postulated that adjuvant cancer treatments and their side effects could trigger sleep disturbances in this population but empirical evidence is lacking. The goal of the current study was to assess, separately in patients with breast and prostate cancer, the effect of adjuvant treatments on the evolution of insomnia symptoms and the mediating role of somatic symptoms.METHODS: As part of a population-based epidemiological study, patients with breast cancer (465 patients) and prostate cancer (263 patients) completed at baseline (perioperative period) and 2 months, 6 months, 10 months, 14 months, and 18 months later the Insomnia Severity Index (ISI) and a questionnaire assessing various somatic symptoms.RESULTS: In patients with breast cancer, radiotherapy (overall effect) and chemotherapy (at 2 months), but not hormone therapy, were associated with increased insomnia severity, whereas androgen deprivation therapy was related to increased insomnia in patients with prostate cancer. In patients with breast cancer, the effect of chemotherapy and radiotherapy on insomnia was found to be significantly mediated by a variety of somatic symptoms, whereas night sweats had a particularly marked mediating role for hormone therapy, both in patients with breast and prostate cancer.CONCLUSIONS: The findings of the current study indicate that cancer treatments and their side effects contribute to the aggravation of insomnia symptoms. Side effects of cancer treatments should be monitored more closely and managed as effectively as possible to prevent the occurrence or aggravation of insomnia.

DOI10.1002/cncr.29244
Alternate JournalCancer
PubMed ID25677509
Grant ListMOP-69073 / / Canadian Institutes of Health Research / Canada