Analysis of DNAJC13 mutations in French-Canadian/French cohort of Parkinson's disease.

TitleAnalysis of DNAJC13 mutations in French-Canadian/French cohort of Parkinson's disease.
Publication TypeJournal Article
Year of Publication2016
AuthorsRoss, JP, Dupré, N, Dauvilliers, Y, Strong, S, Ambalavanan, A, Spiegelman, D, Dionne-Laporte, A, Pourcher, E, Langlois, M, Boivin, M, Leblond, CS, Dion, PA, Rouleau, GA, Gan-Or, iv, Z
JournalNeurobiol Aging
Volume45
Pagination212.e13-212.e17
Date Published2016 Sep
ISSN1558-1497
KeywordsAdult, Aged, Canada, Cohort Studies, European Continental Ancestry Group, Female, France, Genetic Association Studies, Humans, Male, Middle Aged, Molecular Chaperones, Mutation, Parkinson Disease, Sequence Analysis, DNA
Abstract

DNAJC13 mutations have been suggested to cause Parkinson's disease (PD), yet subsequent studies reported conflicting results on this association. In the present study, we sequenced the coding region of DNAJC13 in a French-Canadian/French cohort of 528 PD patients and 692 controls. A total of 62 (11.7%) carriers of rare DNAJC13 variants were identified among the PD patients compared with 82 (11.8%) among controls (p = 1.0). Two variants that were previously suggested to be associated with PD, p.R1516H and p.L2170W, were identified with similar directions of association as previously reported. The p.R1516H was found in 2 (0.4%) patients versus 6 (0.9%, nonsignificant) controls and the p.L2170W variant was found in 9 (1.7%) patients and 5 (0.7%, nonsignificant) controls. Meta-analysis with previous reports resulted in odds ratios of 0.32 (95% confidence interval = 0.15-0.68, p = 0.0037) and 2.68 (95% confidence interval = 1.32-5.42, p = 0.007), respectively. Our results provide some support for the possibility that specific DNAJC13 variants may play a minor role in PD susceptibility, although studies in additional populations are necessary.

DOI10.1016/j.neurobiolaging.2016.04.023
Alternate JournalNeurobiol. Aging
PubMed ID27236598