Tau: A Common Denominator and Therapeutic Target for Neurodegenerative Disorders.

TitleTau: A Common Denominator and Therapeutic Target for Neurodegenerative Disorders.
Publication TypeJournal Article
Year of Publication2018
AuthorsMaxan, A, Cicchetti, F
JournalJ Exp Neurosci
Volume12
Pagination1179069518772380
Date Published2018
ISSN1179-0695
Abstract

There is compelling evidence that a number of neurodegenerative diseases share common pathogenic mechanisms. Better understanding these mechanisms will allow us to develop new therapeutic strategies. This commentary follows up on our recent findings that tau pathology can be found in healthy fetal tissue transplanted into the brain of patients with either Huntington or Parkinson disease. We will examine how tau appears to be shared in a number of different conditions and how its expression relates to cognitive decline and disease progression. We will further review pathogenic mechanisms and especially the relevance of the possible prion-like behavior of tau. We will conclude by discussing how all this work opens up novel therapeutic approaches to treating the cognitive impairments related to neurodegenerative diseases using a common strategy.

DOI10.1177/1179069518772380
Alternate JournalJ Exp Neurosci
PubMed ID29760562
PubMed Central IDPMC5946355