Sex-specific response to hypoxia in a reduced brainstem preparation from Xenopus laevis.

TitleSex-specific response to hypoxia in a reduced brainstem preparation from Xenopus laevis.
Publication TypeJournal Article
Year of Publication2016
AuthorsRousseau, J-P, Fournier, S, Kinkead, R
JournalRespir Physiol Neurobiol
Volume224
Pagination100-3
Date Published2016 Apr
ISSN1878-1519
KeywordsAnimals, Brain Stem, Electrophysiology, Female, Hypoxia, Male, Organ Culture Techniques, Sex Characteristics, Xenopus laevis
Abstract

Respiratory reflexes and tolerance to hypoxia show significant sexual dimorphism. However, the data supporting this notion originates exclusively from mammals. To determine whether this concept is limited to this group of vertebrates, we examined the sex-specific response to acute hypoxia in an adult reduced brainstem preparation from Xenopus laevis. Within the first 5min of exposure to hypoxic aCSF (98% N2/2% CO2), recordings of respiratory-related activity show a stronger increase in fictive breathing frequency in males than females. This initial response was followed by a decrease in respiratory-related activity; this depression occurred 6min sooner in males than females. These results represent new evidences of sexual dimorphism in respiratory control in amphibians and provide potential insight in understanding the homology with other groups of vertebrates, including mammals.

DOI10.1016/j.resp.2015.10.014
Alternate JournalRespir Physiol Neurobiol
PubMed ID26528898