Outcome of cell suspension allografts in a patient with Huntington's disease.

TitleOutcome of cell suspension allografts in a patient with Huntington's disease.
Publication TypeJournal Article
Year of Publication2018
AuthorsMaxan, A, Mason, S, Saint-Pierre, M, Smith, E, Ho, A, Harrower, T, Watts, C, Tai, Y, Pavese, N, Savage, JC, Tremblay, M-È, Gould, P, Rosser, AE, Dunnett, SB, Piccini, P, Barker, RA, Cicchetti, F
JournalAnn Neurol
Date Published2018 Oct 04
ISSN1531-8249
Abstract

For patients with incurable neurodegenerative disorders such as Huntington's (HD) and Parkinson's disease, cell transplantation has been explored as a potential treatment option. Here, we present the first clinicopathological study of a patient with HD in receipt of cell-suspension striatal allografts who took part in the NEST-UK multicenter clinical transplantation trial. Using various immunohistochemical techniques, we found a discrepancy in the survival of grafted projection neurons with respect to grafted interneurons as well as major ongoing inflammatory and immune responses to the grafted tissue with evidence of mutant huntingtin aggregates within the transplant area. Our results indicate that grafts can survive more than a decade post-transplantation, but show compromised survival with inflammation and mutant protein being observed within the transplant site. Ann Neurol 2018; 1-7.

DOI10.1002/ana.25354
Alternate JournalAnn. Neurol.
PubMed ID30286516