|Title||Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Leon-Abarca, JAlonso, Portmann-Baracco, A, Bryce-Alberti, M, Ruiz-Sánchez, C, Accinelli, RAlfonso, Soliz, J, Gonzales, GFrancisco|
|Keywords||Adult, Aged, Altitude, COVID-19, Diabetes Complications, Diabetes Mellitus, Female, Hospitalization, Humans, Intensive Care Units, Male, Mexico, Middle Aged, Prevalence, Risk Factors, SARS-CoV-2, Severity of Illness Index, Survival Rate|
AIMS: The objective of this study is to analyze how the impact of Diabetes Mellitus [DM] in patients with COVID-19 varies according to altitudinal gradient.METHODS: We obtained 1,280,806 records from adult patients with COVID-19 and DM to analyze the probability of COVID-19, development of COVID-19 pneumonia, hospitalization, intubation, admission to the Intensive Care Unit [ICU] and case-fatality rates [CFR]. Variables were controlled by age, sex and altitude of residence to calculate adjusted prevalence and prevalence ratios.RESULTS: Patients with DM had a 21.8% higher prevalence of COVID-19 and an additional 120.2% higher prevalence of COVID-19 pneumonia. The adjusted prevalence was also higher for these outcomes as well as for hospitalization, intubation and ICU admission. COVID-19 and pneumonia patients with DM had a 97.0% and 19.4% higher CFR, respectively. With increasing altitudes, the probability of being a confirmed COVID-19 case and the development of pneumonia decreased along CFR for patients with and without DM. However, COVID-19 patients with DM were more likely to require intubation when residing at high altitude.CONCLUSIONS: The study suggests that patients with DM have a higher probability of being a confirmed COVID-19 case and developing pneumonia. Higher altitude had a protective relationship against SARS-CoV-2 infection; however, it may be associated with more severe cases in patients with and without DM. High altitude decreases CFR for all COVID-19 patients. Our work also shows that women are less affected than men regardless of altitude.
|Alternate Journal||PLoS One|
|PubMed Central ID||PMC8330906|