Role of DSCAM in the Development of Neural Control of Movement and Locomotion.

TitleRole of DSCAM in the Development of Neural Control of Movement and Locomotion.
Publication TypeJournal Article
Year of Publication2021
AuthorsLemieux, M, Thiry, L, Laflamme, OD, Bretzner, F
JournalInt J Mol Sci
Volume22
Issue16
Date Published2021 Aug 07
ISSN1422-0067
KeywordsAnimals, Apoptosis, Axons, Cell Adhesion Molecules, Down Syndrome, Humans, Locomotion, Muscle, Skeletal, Respiratory Mechanics, Synapses
Abstract

Locomotion results in an alternance of flexor and extensor muscles between left and right limbs generated by motoneurons that are controlled by the spinal interneuronal circuit. This spinal locomotor circuit is modulated by sensory afferents, which relay proprioceptive and cutaneous inputs that inform the spatial position of limbs in space and potential contacts with our environment respectively, but also by supraspinal descending commands of the brain that allow us to navigate in complex environments, avoid obstacles, chase prey, or flee predators. Although signaling pathways are important in the establishment and maintenance of motor circuits, the role of DSCAM, a cell adherence molecule associated with Down syndrome, has only recently been investigated in the context of motor control and locomotion in the rodent. DSCAM is known to be involved in lamination and delamination, synaptic targeting, axonal guidance, dendritic and cell tiling, axonal fasciculation and branching, programmed cell death, and synaptogenesis, all of which can impact the establishment of motor circuits during development, but also their maintenance through adulthood. We discuss herein how DSCAM is important for proper motor coordination, especially for breathing and locomotion.

DOI10.3390/ijms22168511
Alternate JournalInt J Mol Sci
PubMed ID34445216
PubMed Central IDPMC8395195
Grant List2018-06218 / / Natural Sciences and Engineering Research Council of Canada /
284011 / / Fonds de Recherche du Québec - Santé /