A vibrissa pathway that activates the limbic system.

TitleA vibrissa pathway that activates the limbic system.
Publication TypeJournal Article
Year of Publication2022
AuthorsElbaz, M, Perez, ACallado, Demers, M, Zhao, S, Foo, C, Kleinfeld, D, Deschênes, M
JournalElife
Volume11
Date Published2022 02 10
ISSN2050-084X
KeywordsAfferent Pathways, Animals, Brain Stem, Electrophysiology, Limbic System, Optogenetics, Rats, Rats, Long-Evans, Trigeminal Nuclei, Vibrissae
Abstract

Vibrissa sensory inputs play a central role in driving rodent behavior. These inputs transit through the sensory trigeminal nuclei, which give rise to the ascending lemniscal and paralemniscal pathways. While lemniscal projections are somatotopically mapped from brainstem to cortex, those of the paralemniscal pathway are more widely distributed. Yet the extent and topography of paralemniscal projections are unknown, along with the potential role of these projections in controlling behavior. Here, we used viral tracers to map paralemniscal projections. We find that this pathway broadcasts vibrissa-based sensory signals to brainstem regions that are involved in the regulation of autonomic functions and to forebrain regions that are involved in the expression of emotional reactions. We further provide evidence that GABAergic cells of the Kölliker-Fuse nucleus gate trigeminal sensory input in the paralemniscal pathway via a mechanism of presynaptic or extrasynaptic inhibition.

DOI10.7554/eLife.72096
Alternate JournalElife
PubMed ID35142608
PubMed Central IDPMC8830883
Grant ListR35 NS097265 / NS / NINDS NIH HHS / United States
U19 NS107466 / NS / NINDS NIH HHS / United States
MT-5877 / / CIHR / Canada