Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment.

TitleDifferential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment.
Publication TypeJournal Article
Year of Publication2022
AuthorsGuma, E, Bordeleau, M, Ibáñez, FGonzález, Picard, K, Snook, E, Desrosiers-Grégoire, G, Spring, S, Lerch, JP, Nieman, BJ, Devenyi, GA, Tremblay, M-È, M Chakravarty, M
JournalProc Natl Acad Sci U S A
Volume119
Issue12
Paginatione2114545119
Date Published2022 Mar 22
ISSN1091-6490
Abstract

SignificancePrenatal exposure to maternal infection increases the risk of developing mental health disorders, such as schizophrenia and autism spectrum disorder. Exposure to maternal immune activation has been associated with a number of neuroanatomical deficits in adolescent and adult offspring, with differing effects based on the gestational timing of infection. However, little is known about how the embryo brain is affected. We show, using whole-brain MRI, that maternal immune activation significantly affects brain anatomy. When the exposure occurs early in pregnancy, volume reductions are mainly observed, while the opposite is true for exposure later in pregnancy. Furthermore, we identify alterations to the density of certain classes of neurons and glia, which have been associated with stress and inflammation in the brain.

DOI10.1073/pnas.2114545119
Alternate JournalProc Natl Acad Sci U S A
PubMed ID35286203
PubMed Central IDPMC8944668
Grant ListNA / / Fonds de Recherche du Québec - Santé (FRQS) /
NA / / Fonds de Recherche du Québec - Nature et Technologies (FRQNT) /
NA / / Gouvernement du Canada | Canadian Institutes of Health Research (CIHR) /