|Title||Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia.|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Guisle, I, Canet, G, Pétry, S, Fereydouni-Forouzandeh, P, Morin, F, Kérauden, R, Whittington, RA, Calon, F, Hébert, SS, Planel, E|
|Date Published||2022 Feb 26|
In Alzheimer's disease (AD), hyper-phosphorylation and aggregation of tau correlate with clinical progression and represent a valid therapeutic target. A recent 20-year prospective study revealed an association between moderate to high frequency of Finnish sauna bathing and a lower incidence of dementia and AD, but the molecular mechanisms underlying these benefits remain uncertain. Here, we tested the hypothesis that sauna-like conditions could lower tau phosphorylation by increasing body temperature. We observed a decrease in tau phosphorylation in wild-type and hTau mice as well as in neuron-like cells when exposed to higher temperatures. These effects were correlated with specific changes in phosphatase and kinase activities, but not with inflammatory or heat shock responses. We also used a drug strategy to promote thermogenesis: topical application of menthol, which led to a sustained increase in body temperature in hTau mice, concomitant with a significant decrease in tau phosphorylation. Our results suggest that sauna-like conditions or menthol treatment could lower tau pathology through mild hyperthermia, and may provide promising therapeutic strategies for AD and other tauopathies.
|Alternate Journal||Neurobiol Aging|