Ionic and synaptic mechanisms of seizure generation and epileptogenesis.

TitleIonic and synaptic mechanisms of seizure generation and epileptogenesis.
Publication TypeJournal Article
Year of Publication2019
AuthorsGonzález, OC, Krishnan, GP, Timofeev, I, Bazhenov, M
JournalNeurobiol Dis
Volume130
Pagination104485
Date Published2019 May 28
ISSN1095-953X
Abstract

The biophysical mechanisms underlying epileptogenesis and the generation of seizures remain to be better understood. Among many factors triggering epileptogenesis are traumatic brain injury breaking normal synaptic homeostasis and genetic mutations disrupting ionic concentration homeostasis. Impairments in these mechanisms, as seen in various brain diseases, may push the brain network to a pathological state characterized by increased susceptibility to unprovoked seizures. Here, we review recent computational studies exploring the roles of ionic concentration dynamics in the generation, maintenance, and termination of seizures. We further discuss how ionic and synaptic homeostatic mechanisms may give rise to conditions which prime brain networks to exhibit recurrent spontaneous seizures and epilepsy.

DOI10.1016/j.nbd.2019.104485
Alternate JournalNeurobiol. Dis.
PubMed ID31150792