Inflammatory mechanisms in neurodegeneration.

TitleInflammatory mechanisms in neurodegeneration.
Publication TypeJournal Article
Year of Publication2019
AuthorsNichols, MR, St-Pierre, M-K, Wendeln, A-C, Makoni, NJ, Gouwens, LK, Garrad, EC, Sohrabi, M, Neher, JJ, Tremblay, M-È, Combs, CK
JournalJ Neurochem
Date Published2019 Jan 31
ISSN1471-4159
Abstract

This review discusses the profound connection between microglia, neuroinflammation, and Alzheimer's disease (AD). Theories have been postulated, tested, and modified over several decades. The findings have further bolstered the belief that microglia-mediated inflammation is both a product and contributor to AD pathology and progression. Distinct microglia phenotypes and their function, microglial recognition and response to protein aggregates in AD, and the overall role of microglia in AD are areas that have received considerable research attention and yielded significant results. The following article provides a historical perspective of microglia, a detailed discussion of multiple microglia phenotypes including dark microglia, and a review of a number of areas where microglia intersect with AD and other pathological neurological processes. The overall breadth of important discoveries achieved in these areas significantly strengthens the hypothesis that neuroinflammation plays a key role in AD. Future determination of the exact mechanisms by which microglia respond to, and attempt to mitigate, protein aggregation in AD may lead to new therapeutic strategies.

DOI10.1111/jnc.14674
Alternate JournalJ. Neurochem.
PubMed ID30702751
Grant List / / Canada Research Chairs /
R15AG033913 / / National Institute on Aging /
/ / Fonds de recherche du Québec-Santé (FRQS) /
R15 AG033913 / AG / NIA NIH HHS / United States
/ / Canadian Institutes of Health Research /