Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus.

TitleConnectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus.
Publication TypeJournal Article
Year of Publication2018
AuthorsFrancavilla, R, Villette, V, Luo, X, Chamberland, S, Muñoz-Pino, E, Camiré, O, Wagner, K, Kis, V, Somogyi, P, Topolnik, L
JournalNat Commun
Volume9
Issue1
Pagination5043
Date Published2018 11 28
ISSN2041-1723
KeywordsAnimals, CA1 Region, Hippocampal, Female, GABAergic Neurons, Hippocampus, Interneurons, Male, Mice, Pyramidal Cells, Vasoactive Intestinal Peptide
Abstract

GABAergic interneurons in the hippocampus provide for local and long-distance coordination of neurons in functionally connected areas. Vasoactive intestinal peptide-expressing (VIP+) interneurons occupy a distinct niche in circuitry as many of them specialize in innervating GABAergic cells, thus providing network disinhibition. In the CA1 hippocampus, VIP+ interneuron-selective cells target local interneurons. Here, we discover a type of VIP+ neuron whose axon innervates CA1 and also projects to the subiculum (VIP-LRPs). VIP-LRPs show specific molecular properties and target interneurons within the CA1 area but both interneurons and pyramidal cells within subiculum. They are interconnected through gap junctions but demonstrate sparse spike coupling in vitro. In awake mice, VIP-LRPs decrease their activity during theta-run epochs and are more active during quiet wakefulness but not coupled to sharp-wave ripples. Together, the data provide evidence for VIP interneuron molecular diversity and functional specialization in controlling cell ensembles along the hippocampo-subicular axis.

DOI10.1038/s41467-018-07162-5
Alternate JournalNat Commun
PubMed ID30487571
PubMed Central IDPMC6261953