Comprehension of concrete and abstract words in semantic variant primary progressive aphasia and Alzheimer's disease: A behavioral and neuroimaging study.

TitleComprehension of concrete and abstract words in semantic variant primary progressive aphasia and Alzheimer's disease: A behavioral and neuroimaging study.
Publication TypeJournal Article
Year of Publication2017
AuthorsJoubert, S, Vallet, GT, Montembeault, M, Boukadi, M, Wilson, MA, Laforce, Jr, R, Rouleau, I, Brambati, SM
JournalBrain Lang
Volume170
Pagination93-102
Date Published2017 Jul
ISSN1090-2155
KeywordsAged, Alzheimer Disease, Aphasia, Primary Progressive, Atrophy, Brain, Case-Control Studies, Comprehension, Emotions, Female, Humans, Judgment, Language, Magnetic Resonance Imaging, Male, Neuroimaging, Neuropsychological Tests, Semantics, Temporal Lobe
Abstract

The aim of this study was to investigate the comprehension of concrete, abstract and abstract emotional words in semantic variant primary progressive aphasia (svPPA), Alzheimer's disease (AD), and healthy elderly adults (HE) Three groups of participants (9 svPPA, 12 AD, 11 HE) underwent a general neuropsychological assessment, a similarity judgment task, and structural brain MRI. The three types of words were processed similarly in the group of AD participants. In contrast, patients in the svPPA group were significantly more impaired at processing concrete words than abstract words, while comprehension of abstract emotional words was in between. VBM analyses showed that comprehension of concrete words relative to abstract words was significantly correlated with atrophy in the left anterior temporal lobe. These results support the view that concrete words are disproportionately impaired in svPPA, and that concrete and abstract words may rely upon partly dissociable brain regions.

DOI10.1016/j.bandl.2017.04.004
Alternate JournalBrain Lang
PubMed ID28432988