Calcium Dynamics in Dendrites of Hippocampal CA1 Interneurons in Awake Mice.

TitleCalcium Dynamics in Dendrites of Hippocampal CA1 Interneurons in Awake Mice.
Publication TypeJournal Article
Year of Publication2019
AuthorsFrancavilla, R, Villette, V, Martel, O, Topolnik, L
JournalFront Cell Neurosci
Volume13
Pagination98
Date Published2019
ISSN1662-5102
Abstract

Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca signals and, accordingly, the recruitment of hippocampal interneurons in awake behaving animals. However, little is still known about dendritic Ca activity in interneurons during different behavioral states. Here, we used two-photon Ca imaging in mouse hippocampal CA1 interneurons to reveal Ca signal patterns in interneuron dendrites during animal locomotion and immobility. Despite overall variability in dendritic Ca transients (CaTs) across different cells and dendritic branches, we report consistent behavior state-dependent organization of Ca signaling in interneurons. As such, spreading regenerative CaTs dominated in dendrites during locomotion, whereas both spreading and localized Ca signals were seen during immobility. Thus, these data indicate that while animal locomotion is associated with widespread Ca elevations in interneuron dendrites that may reflect regenerative activity, local CaTs that may be related to synaptic activity become apparent during animal quiet state.

DOI10.3389/fncel.2019.00098
Alternate JournalFront Cell Neurosci
PubMed ID30930750
PubMed Central IDPMC6428725